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September 10 2019

What does the "entourage effect" do?


... 1 + 1 makes 5 ... or something. The entourage effect is one of thousands of natural wonders and the best example of how sophisticated Biochemistry can work.

The entourage effect refers to the interactive synergy of herbal ingredients in cannabis. More simply, this means that a mixture of plant compounds has a higher biological activity than a pure substance.

Every single cannabinoid has no doubt its own effect, but through interaction with other cannabinoids and terpenes, a multitude of other effects that contribute to the enhancement of the action and / or to the improvement of the action are created.
Cannabinoids are not only synthesized by cannabis plants, but also in our body by the so-called endocannabinoid system (ECS), which controls important functions such as anxiety, cognition, sleep and appetite.

The effect of the endocannabinoids can of course be enhanced by external administration such as marijuana use.

The self-made endocannabinoids need to bind to the cannabinoid receptors CB1 and / or CB2, which then pass the signal through ion channels to develop their effects.
THC binds mainly to CB1 receptors, which are mainly found in gonads, glands, other organs, in the brain and in the central nervous system (CNS).

It contributes to a euphoric and psychoactive "high" - feeling and has an analgesic effect. CBD, on the other hand, also binds with low affinity to CB1 receptors, thereby acting as an antagonist to THC, thereby reducing or affecting some of the effects caused by THC.

It also has a higher affinity for CB2 receptors found in organs such as the spleen, tonsils, and thymus gland. It regulates, among other things, intestinal inflammatory reactions and the immune system. It also prevents the breakdown of natural cannabinoids and can regulate receptors that are important for physical and mental health.
There is a general belief that plants are better drugs than the substrates isolated from them. Studies have shown that herbal extracts delivered 2 to 4 times stronger effects than pure THC.

The interaction of both cannabinoids can lead to beneficial effects on the body and psyche. For example, consumption of pure THC can trigger stress and anxiety. The calming effect of CBD, however, can counteract this and provide relaxation and positive emotions.

In addition, it has been repeatedly reported that CBD could increase the analgesic properties of THC.
In fact, CBD and THC are in the focus of science, but also terpenes contribute to the entourage effect.

Terpenes share the same synthetic precursor with phytocannabinoids and are responsible for the often refreshing smell and taste of plants and their fruits, such as mangos or lemons. They can also influence the behavior of humans and animals.
The terpene limonene for example, contained in citrus fruits, mint and rosemary but also in cannabis, is responsible for the refreshing citrus-like odor, but should also contribute to mental well-being and stress reduction.

It also has an antibacterial, fungicidal and anti-cancer effect, while stimulating the immune system. In conjunction with another terpene linalool and the cannabinoid CBG it is said to have potential for the treatment of MRSA, popularly called "hospital bacteria".
But how do terpenes actually work? After all, they are not compatible with the cannabinoid receptors and therefore can not actively participate in it. However, scientists have discovered that terpenes can affect the amount of THC entering the brain through the blood-brain barrier, and that terpenes can also directly affect neurotransmitters.
To what extent this has a good or bad effect on "high" sensation or physical effects depends on the composition and amount of terpenes contained in each cannabis strain.

A good example at this point is the so-called mango myth. Many of you have probably heard that consuming a well-matured mango about 45 minutes before consuming marijuana enhances the psychoactive effect of THC and no, that's not a myth!

That actually works!
The terpene myrcene from the mango, also contained in some cannabis species, interacts with THC and enhances its action. It is now also known that myrcene is usually contained in indica varieties and can contribute to the so-called "couch lock" effect.
If you would like to know more about the topic "Entourage effect", we can refer to the comprehensive studies and detailed publications by Dr. med. Highly recommend Ethan Russo.
Finally, it is important to emphasize how important this research is. Cannabis contains an incredible amount of cannabinoids and terpenes and every single substrate has its own effect.

But the interaction of all these substrates creates an infinite number of effects that we could all control if we knew more about the interactions.

This, in turn, could lead to a variety of therapeutic approaches that, mind you, would all be based on the herbal properties of cannabis.
Source:420queenz.de

Reposted frompsychedelix psychedelix

August 23 2019

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August 21 2019

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Cannabis-Wirkstoff ist 30 Mal effektiver als Aspirin

In Cannabis enthaltende Moleküle haben eine 30 Mal stärkere schmerzlindernde Wirkung als Aspirin (Wirkstoff Acetylsalicylsäure).
Das haben Forscher der kanadischen Universität in Guelph herausgefunden.

Damit schaffen die Wissenschaftler eine Grundlage für neue Schmerzbehandlungen, ohne dass die Gefahr einer Abhängigkeit entsteht wie beispielsweise bei Opioiden.
Quelle: wize.life


Reposted frompsychedelix psychedelix
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